Regulation of lamellipodium organization

Across TCGA patient cohorts, RNA activity of the Regulation of lamellipodium organization pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR3193, FOXK2, and EIF3M, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lamellipodium organization activity versus MIR3193 in LUAD (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR3193 →	+0.899	+0.088	<.001	<.001	3	5
BRCA	FOXK2 →	-0.457	-0.228	.006	<.001	3	4
BRCA	EIF3M →	-0.347	-0.188	<.001	<.001	3	4
BRCA	TMED9 →	-0.328	-0.158	.005	.006	3	4
LUAD	ID1 →	+1.369	+0.118	<.001	.001	3	4
LSCC	ETS2 →	+0.638	+0.116	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902743 vs MIR3193 — LUAD

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