Apoptotic process involved in development

Across TCGA patient cohorts, RNA activity of the Apoptotic process involved in development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MMP2, FILIP1L, and HSPG2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apoptotic process involved in development activity versus MMP2 in LSCC (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MMP2 →	+0.668	+0.042	<.001	.001	3	7
CCRCC	FILIP1L →	+0.496	+0.025	<.001	<.001	3	6
OV	HSPG2 →	+0.495	+0.050	<.001	<.001	3	6
CCRCC	VCL →	+0.550	+0.043	<.001	<.001	3	6
LSCC	FN1 →	+0.423	+0.032	.002	<.001	3	6
CCRCC	LMCD1 →	+0.503	+0.027	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902742 vs MMP2 — LSCC

Explore this scatter interactively →