Apoptotic process involved in development

Across TCGA patient cohorts, RNA activity of the Apoptotic process involved in development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM241B, GPAA1, and CYC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apoptotic process involved in development activity versus FAM241B in CCRCC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FAM241B →	+0.271	+0.411	.008	.001	3	4
BRCA	GPAA1 →	+0.711	+0.539	<.001	.005	3	4
UCEC	CYC1 →	+1.078	+0.961	<.001	.001	3	4
BRCA	TIGD5 →	+0.606	+0.683	<.001	<.001	3	4
BRCA	SCRIB →	+0.785	+0.835	<.001	<.001	3	4
BRCA	TOP1MT →	+0.748	+0.905	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902742 vs FAM241B — CCRCC

Explore this scatter interactively →