Apoptotic process involved in development

Across TCGA cell cohorts, RNA activity of the Apoptotic process involved in development pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STIM1, FBXO32, and CLCF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STIM1 grouped by Apoptotic process involved in development-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	STIM1 →	-1.396	-1.209	.005	.007	3	5
LIVER	FBXO32 →	-3.200	-1.418	.002	<.001	3	5
OESOPHAGUS	CLCF1 →	-1.091	-0.954	.004	<.001	3	4
LUNG_NSCLC_LUSC	TSSC4 →	-0.783	-1.042	.001	.009	3	4
CNS	FSTL3 →	-1.679	-0.958	.008	.001	3	4
LIVER	RNF141 →	-0.751	-1.261	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STIM1 by Apoptotic process involved in development activity — STOMACH

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