Positive regulation of chondrocyte proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of chondrocyte proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOXD4, LINC01003, and AXIN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of chondrocyte proliferation activity versus HOXD4 in LUAD (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HOXD4 →	+0.809	+0.347	<.001	<.001	3	4
BRCA	LINC01003 →	+0.410	+0.467	.005	.007	3	4
UCEC	AXIN2 →	+1.439	+0.309	<.001	<.001	3	3
UCEC	FAM86DP →	+0.447	+0.179	.003	.007	3	3
LUAD	BCAS1 →	-1.334	-0.302	<.001	.005	3	3
LUAD	HOXD3 →	+0.618	+0.310	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902732 vs HOXD4 — LUAD

Explore this scatter interactively →