Positive regulation of chondrocyte proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of chondrocyte proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RDH8, OR56A1, and PER2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RDH8 grouped by Positive regulation of chondrocyte proliferation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RDH8 →	-0.243	-0.204	<.001	.003	3	5
STOMACH	OR56A1 →	+0.144	+0.227	.006	.003	3	4
BLOOD_Lymphoma	PER2 →	-0.282	-0.281	<.001	<.001	3	4
BLOOD_Leukemia	FMOD →	-0.180	-0.367	<.001	<.001	3	4
LARGE_INTESTINE	FCHSD2 →	+0.176	+0.137	.002	.007	3	4
OESOPHAGUS	ATP6V1A →	+0.335	+0.228	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RDH8 by Positive regulation of chondrocyte proliferation activity — SKIN

Explore this box plot interactively →