Regulation of neuroblast proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of neuroblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPE, EFNB3, and SEMA5A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuroblast proliferation activity versus CPE in LSCC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CPE →	+1.039	+0.454	<.001	.004	3	4
PDAC	EFNB3 →	+0.427	+0.768	<.001	.001	3	4
PDAC	SEMA5A →	+0.622	+0.797	<.001	<.001	3	4
PDAC	CDH11 →	+0.975	+0.855	<.001	<.001	3	4
PDAC	COL8A1 →	+0.967	+0.881	<.001	<.001	2	5
PDAC	DGKI →	+0.543	+0.758	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902692 vs CPE — LSCC

Explore this scatter interactively →