Regulation of neuroblast proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of neuroblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFSD9, CNNM3, and STAC, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MFSD9 grouped by Regulation of neuroblast proliferation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	MFSD9 →	+0.722	+1.363	.003	.002	3	7
KIDNEY	CNNM3 →	+0.695	+0.870	.006	.004	3	5
LIVER	STAC →	-2.580	-1.035	<.001	.001	3	5
LUNG_NSCLC_LUAD	CBLC →	+1.592	+0.346	.009	.009	3	4
KIDNEY	PLLP →	+1.211	+0.946	.007	.009	3	4
KIDNEY	AKAP1 →	+0.651	+1.333	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MFSD9 by Regulation of neuroblast proliferation activity — KIDNEY

Explore this box plot interactively →