Regulation of neuroblast proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of neuroblast proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGPAT3, LRRC15, and GCFC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGPAT3 grouped by Regulation of neuroblast proliferation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AGPAT3 →	+0.274	+1.339	.004	<.001	3	3
OESOPHAGUS	LRRC15 →	+0.116	+0.307	<.001	<.001	3	3
LUNG_SCLC	GCFC2 →	-0.194	-1.126	<.001	.003	3	3
BONE	NXNL1 →	+0.536	+1.767	.008	.002	3	3
BONE	HNRNPA0 →	+0.245	+1.681	.002	<.001	3	3
OESOPHAGUS	HSD3B7 →	-0.153	-0.270	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGPAT3 by Regulation of neuroblast proliferation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →