Regulation of receptor localization to synapse

Across TCGA patient cohorts, RNA activity of the Regulation of receptor localization to synapse pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GPC6, COL1A1, and P3H3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of receptor localization to synapse activity versus GPC6 in LSCC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GPC6 →	+0.567	+0.060	<.001	<.001	3	9
COAD	COL1A1 →	+0.765	+0.042	.001	<.001	3	8
CCRCC	P3H3 →	+0.502	+0.054	.003	.001	3	8
COAD	COL1A2 →	+0.812	+0.035	<.001	<.001	3	8
LSCC	CTHRC1 →	+0.706	+0.061	<.001	<.001	3	8
PDAC	SGCE →	+0.402	+0.046	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902683 vs GPC6 — LSCC

Explore this scatter interactively →