Positive regulation of axon guidance

Across TCGA patient cohorts, RNA activity of the Positive regulation of axon guidance pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBB2B, LOXL2, and MFGE8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of axon guidance activity versus TUBB2B in LSCC (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TUBB2B →	+1.755	+0.479	<.001	<.001	3	5
BRCA	LOXL2 →	+1.082	+0.803	.001	.001	3	4
BRCA	MFGE8 →	+1.256	+0.872	.001	<.001	3	4
LSCC	SV2A →	+0.729	+0.427	<.001	<.001	3	4
OV	BRSK1 →	+1.206	+1.130	<.001	<.001	3	4
BRCA	DCLK2 →	+0.961	+0.817	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902669 vs TUBB2B — LSCC

Explore this scatter interactively →