Positive regulation of axon guidance

Across TCGA cell cohorts, RNA activity of the Positive regulation of axon guidance pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRK3, HTR4, and OR2AT4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GRK3 grouped by Positive regulation of axon guidance-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GRK3 →	+0.385	+1.850	<.001	<.001	3	4
URINARY_TRACT	HTR4 →	+0.307	+1.840	<.001	<.001	3	4
BREAST	OR2AT4 →	-0.175	-1.347	<.001	<.001	3	4
BREAST	ADSL →	-0.321	-1.040	.001	<.001	3	4
LUNG_SCLC	ZNF709 →	+0.233	+0.398	.003	.002	3	4
BLOOD_Lymphoma	AKAP9 →	-0.237	-1.847	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GRK3 by Positive regulation of axon guidance activity — URINARY_TRACT

Explore this box plot interactively →