Regulation of axon guidance

Across TCGA patient cohorts, RNA activity of the Regulation of axon guidance pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NRP1, IGFBP3, and EVL_S246, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of axon guidance activity versus NRP1 in GBM (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NRP1 →	+0.665	+0.102	.001	<.001	3	5
GBM	IGFBP3 →	+0.763	+0.070	.001	.002	3	5
HNSC	EVL_S246 →	-0.858	-0.129	<.001	<.001	3	5
GBM	MPO →	+0.875	+0.068	<.001	<.001	3	5
GBM	S100A10 →	+0.556	+0.085	.007	<.001	3	5
GBM	TMOD3 →	+0.265	+0.074	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902667 vs NRP1 — GBM

Explore this scatter interactively →