Regulation of axon guidance

Across TCGA cell cohorts, RNA activity of the Regulation of axon guidance pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNASE4, STMN3, and GINM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of axon guidance activity versus RNASE4 in BLOOD_Lymphoma (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	RNASE4 →	-1.112	-0.846	<.001	<.001	3	5
LUNG_SCLC	STMN3 →	+2.367	+0.918	.002	<.001	3	5
BONE	GINM1 →	-0.995	-1.253	.001	.003	3	4
BLOOD_Lymphoma	HNRNPA1 →	+0.481	+0.863	.008	.003	3	4
BLOOD_Lymphoma	JAZF1 →	+1.945	+0.918	.008	.004	3	4
LUNG_SCLC	MSI2 →	+1.611	+1.075	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902667 vs RNASE4 — BLOOD_Lymphoma

Explore this scatter interactively →