Tertiary alcohol metabolic process

Across TCGA patient cohorts, RNA activity of the Tertiary alcohol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNT4, CACNA1H, and ABCB6, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tertiary alcohol metabolic process activity versus WNT4 in ACC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	WNT4 →	+2.088	+0.039	<.001	<.001	3	18
KICH	CACNA1H →	+1.679	+0.054	<.001	<.001	3	18
LUAD	ABCB6 →	+0.681	+0.042	<.001	<.001	3	17
TGCT	BMP2 →	+1.097	+0.042	<.001	<.001	3	17
LUAD	AKR1C3 →	+2.562	+0.072	<.001	<.001	3	17
LUAD	TRIM16L →	+1.292	+0.045	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902644 vs WNT4 — ACC

Explore this scatter interactively →