Tertiary alcohol metabolic process

Across TCGA patient cohorts, RNA activity of the Tertiary alcohol metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1C2, AKR1C3, and CEP170, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tertiary alcohol metabolic process activity versus AKR1C2 in UCEC (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AKR1C2 →	+1.838	+0.071	<.001	.006	3	7
LSCC	AKR1C3 →	+1.494	+0.114	<.001	<.001	3	7
PDAC	CEP170 →	-0.211	-0.084	<.001	<.001	3	6
LUAD	AKR1B10 →	+2.308	+0.078	<.001	<.001	3	6
LSCC	ME1 →	+0.753	+0.113	<.001	<.001	3	6
LUAD	RAP1GAP_S484 →	+0.758	+0.066	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902644 vs AKR1C2 — UCEC

Explore this scatter interactively →