Tertiary alcohol metabolic process

Across TCGA patient cohorts, RNA activity of the Tertiary alcohol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1B10, ARHGAP24, and AKR1C2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tertiary alcohol metabolic process activity versus AKR1B10 in LSCC (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1B10 →	+2.732	+0.146	<.001	<.001	3	6
GBM	ARHGAP24 →	+0.754	+0.158	<.001	<.001	3	6
LSCC	AKR1C2 →	+2.493	+0.127	<.001	<.001	3	6
LSCC	AKR1C1 →	+2.136	+0.117	<.001	<.001	3	6
LSCC	AKR1C3 →	+2.110	+0.138	<.001	<.001	3	6
GBM	PGAP4 →	+1.041	+0.144	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902644 vs AKR1B10 — LSCC

Explore this scatter interactively →