Positive regulation of neutrophil migration

Across TCGA patient cohorts, RNA activity of the Positive regulation of neutrophil migration pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BDP1, EXOSC2, and REXO4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neutrophil migration activity versus BDP1 in LSCC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BDP1 →	-0.350	-0.182	.005	.003	3	6
LSCC	EXOSC2 →	-0.413	-0.170	.001	.003	3	6
LSCC	REXO4 →	-0.353	-0.228	.006	.001	3	6
BRCA	GSTCD →	-0.544	-0.141	.002	.003	3	6
LSCC	CLUAP1 →	-0.640	-0.256	<.001	<.001	3	5
COAD	PSMD9 →	-0.156	-0.141	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902624 vs BDP1 — LSCC

Explore this scatter interactively →