Positive regulation of neutrophil migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of neutrophil migration pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACAD9, RDH14, and PAX7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACAD9 grouped by Positive regulation of neutrophil migration-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ACAD9 →	-0.232	-0.124	.003	.005	3	5
OESOPHAGUS	RDH14 →	-0.185	-0.157	<.001	<.001	3	5
BONE	PAX7 →	+0.534	+0.245	<.001	.001	3	4
BONE	CBX6 →	-0.216	-0.225	<.001	<.001	3	4
OVARY	SMPD2 →	-0.142	-0.159	.001	.001	3	4
URINARY_TRACT	RECQL →	-0.140	-0.159	.009	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACAD9 by Positive regulation of neutrophil migration activity — BREAST

Explore this box plot interactively →