Positive regulation of neutrophil migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of neutrophil migration pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD99, FOSL1, and AHNAK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neutrophil migration activity versus CD99 in STOMACH (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CD99 →	+2.548	+0.397	.001	<.001	3	6
SOFT_TISSUE	FOSL1 →	+4.942	+0.306	.008	.001	3	5
OVARY	AHNAK →	+2.060	+0.295	.009	.003	3	5
SOFT_TISSUE	PTCD3 →	-0.976	-0.223	.005	.003	3	5
UPPER_AERODIGESTIVE_TRACT	TWF2 →	+0.535	+0.147	.001	.005	3	5
BLOOD_Leukemia	TRIOBP →	+0.655	+0.203	.002	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902624 vs CD99 — STOMACH

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