Negative regulation of neutrophil migration

Across TCGA patient cohorts, RNA activity of the Negative regulation of neutrophil migration pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDGFRB, CNRIP1, and FSTL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neutrophil migration activity versus PDGFRB in BRCA (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PDGFRB →	+0.903	+0.690	<.001	<.001	3	6
BRCA	CNRIP1 →	+0.952	+0.901	<.001	<.001	3	6
BRCA	FSTL1 →	+0.913	+0.688	<.001	<.001	3	6
BRCA	LMOD1 →	+0.778	+0.688	<.001	<.001	3	6
PDAC	CD200 →	+0.449	+0.081	<.001	<.001	3	6
BRCA	LAMB1 →	+0.733	+0.607	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902623 vs PDGFRB — BRCA

Explore this scatter interactively →