Carnitine transmembrane transport

Across TCGA patient cohorts, RNA activity of the Carnitine transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAP, P3H3, and PLOD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carnitine transmembrane transport activity versus FAP in HNSC (Pearson r = -0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FAP →	-0.451	-0.054	.008	.001	2	7
PDAC	P3H3 →	-0.452	-0.068	<.001	<.001	3	6
BRCA	PLOD1 →	-0.605	-0.095	<.001	<.001	3	6
BRCA	P3H1 →	-0.515	-0.083	<.001	<.001	3	6
BRCA	PCBD2 →	+0.507	+0.076	<.001	<.001	3	6
GBM	ALDH7A1 →	+0.328	+0.056	.003	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902603 vs FAP — HNSC

Explore this scatter interactively →