Carnitine transmembrane transport

Across TCGA patient cohorts, RNA activity of the Carnitine transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC6A14, GK, and GK-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carnitine transmembrane transport activity versus SLC6A14 in HNSC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLC6A14 →	+2.985	+0.960	<.001	<.001	3	4
LUAD	GK →	+0.541	+0.467	<.001	.007	3	3
LUAD	GK-AS1 →	+0.590	+0.596	<.001	<.001	3	3
UCEC	RDH10-AS1 →	+1.615	+0.225	<.001	.004	3	3
UCEC	NCOA7 →	+0.650	+0.172	.002	<.001	2	4
UCEC	RIMKLBP2 →	-1.056	-0.221	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902603 vs SLC6A14 — HNSC

Explore this scatter interactively →