Carnitine transmembrane transport

Across TCGA cell cohorts, RNA activity of the Carnitine transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PBX3, ATP6V1B2, and AP3S1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PBX3 grouped by Carnitine transmembrane transport-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PBX3 →	-1.205	-1.666	.003	<.001	2	5
LUNG_NSCLC_LUAD	ATP6V1B2 →	-0.639	-1.244	.002	<.001	3	4
PANCREAS	AP3S1 →	-0.586	-1.538	.002	<.001	3	3
LARGE_INTESTINE	PITPNM2 →	-1.088	-1.611	.002	<.001	3	3
BREAST	SEC31A →	-0.453	-0.692	.003	.001	3	3
STOMACH	FANCL →	+0.617	+1.223	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PBX3 by Carnitine transmembrane transport activity — OESOPHAGUS

Explore this box plot interactively →