Proton transmembrane transport

Across TCGA patient cohorts, RNA activity of the Proton transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MSRB2, GNAO1, and SRSF3_S5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proton transmembrane transport activity versus MSRB2 in GBM (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MSRB2 →	+0.373	+0.053	.002	<.001	3	7
GBM	GNAO1 →	+0.645	+0.042	<.001	.002	3	5
PDAC	SRSF3_S5 →	-0.499	-0.030	<.001	<.001	3	5
GBM	UTP25 →	-0.205	-0.034	.001	<.001	3	5
LSCC	ABR_T74 →	+0.468	+0.027	<.001	<.001	3	5
COAD	CLYBL →	+0.425	+0.015	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902600 vs MSRB2 — GBM

Explore this scatter interactively →