Proton transmembrane transport

Across TCGA patient cohorts, RNA activity of the Proton transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C18orf54, RBMS1, and MAML2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proton transmembrane transport activity versus C18orf54 in CCRCC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	C18orf54 →	-0.499	-0.177	.001	<.001	2	8
GBM	RBMS1 →	-0.655	-0.214	<.001	.002	3	6
LUAD	MAML2 →	-0.484	-0.104	.001	.004	3	6
OV	C11orf58 →	-0.457	-0.116	<.001	.008	3	5
UCEC	LOXL3 →	-0.592	-0.194	<.001	.002	3	5
OV	TARDBP →	-0.289	-0.110	.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902600 vs C18orf54 — CCRCC

Explore this scatter interactively →