Proton transmembrane transport

Across TCGA cell cohorts, RNA activity of the Proton transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD86, IFNGR1, and CREB3L2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD86 grouped by Proton transmembrane transport-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CD86 →	+0.061	+0.205	.004	.003	3	4
LIVER	IFNGR1 →	-1.022	-0.300	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	CREB3L2 →	-1.103	-0.264	.005	.001	3	4
BREAST	CCDC9B →	-2.142	-0.215	<.001	.002	3	4
BREAST	PLEKHA4 →	-1.384	-0.204	.006	.002	3	4
BREAST	B4GALT5 →	-1.133	-0.223	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD86 by Proton transmembrane transport activity — SOFT_TISSUE

Explore this box plot interactively →