Proton transmembrane transport

Across TCGA cell cohorts, RNA activity of the Proton transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SF3A3, SKP2, and INCENP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proton transmembrane transport activity versus SF3A3 in STOMACH (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SF3A3 →	-0.715	-0.313	.006	.003	3	6
LARGE_INTESTINE	SKP2 →	-1.033	-0.225	.006	.004	3	6
BLOOD_Leukemia	INCENP →	-0.962	-0.202	.002	.002	3	5
BREAST	SCLT1 →	-0.762	-0.228	<.001	<.001	3	5
LUNG_SCLC	ERCC2 →	-0.592	-0.206	.002	<.001	3	5
LUNG_SCLC	BSCL2 →	+1.336	+0.230	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902600 vs SF3A3 — STOMACH

Explore this scatter interactively →