Protein localization to nucleolus

Across TCGA patient cohorts, RNA activity of the Protein localization to nucleolus pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX47, CMSS1, and POLR2H, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to nucleolus activity versus DDX47 in BRCA (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDX47 →	+0.420	+0.032	<.001	.003	3	7
LSCC	CMSS1 →	+0.659	+0.071	<.001	<.001	3	6
HNSC	POLR2H →	+0.187	+0.071	.001	<.001	3	6
BRCA	TPR →	+0.222	+0.043	<.001	<.001	3	6
LSCC	DRG1 →	+0.196	+0.042	.001	.001	3	6
UCEC	ZC3H8 →	+0.382	+0.076	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902570 vs DDX47 — BRCA

Explore this scatter interactively →