Protein localization to nucleolus

Across TCGA cell cohorts, RNA activity of the Protein localization to nucleolus pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCP3, TGFBI, and AK4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UCP3 grouped by Protein localization to nucleolus-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	UCP3 →	-0.592	-0.253	.005	<.001	3	4
LARGE_INTESTINE	TGFBI →	-4.440	-0.229	<.001	<.001	3	4
LARGE_INTESTINE	AK4 →	+2.286	+0.244	<.001	<.001	3	4
LARGE_INTESTINE	EIF4B →	+0.565	+0.192	.002	.002	3	4
PANCREAS	AGO3 →	+0.709	+0.155	.009	.008	3	3
PANCREAS	FAM210A →	+0.872	+0.181	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UCP3 by Protein localization to nucleolus activity — STOMACH

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