Protein localization to nucleolus

Across TCGA cell cohorts, RNA activity of the Protein localization to nucleolus pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KBTBD7, ARFIP1, and CNTNAP3B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to nucleolus activity versus KBTBD7 in OESOPHAGUS (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	KBTBD7 →	-0.890	-0.254	<.001	.001	3	5
BREAST	ARFIP1 →	-0.643	-0.185	.005	.006	3	5
LIVER	CNTNAP3B →	+4.552	+0.408	.003	.002	3	5
CNS	HERC3 →	-1.261	-0.187	.004	.005	3	5
OESOPHAGUS	PEX7 →	-1.287	-0.208	.001	.005	2	5
SOFT_TISSUE	CTNNBL1 →	+0.705	+0.220	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902570 vs KBTBD7 — OESOPHAGUS

Explore this scatter interactively →