Negative regulation of neutrophil activation

Across TCGA patient cohorts, RNA activity of the Negative regulation of neutrophil activation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC30A4, MAPK1, and GPR75, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neutrophil activation activity versus SLC30A4 in CCRCC (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SLC30A4 →	+0.224	+0.594	.002	<.001	3	4
GBM	MAPK1 →	+0.361	+0.543	.002	.002	3	3
OV	GPR75 →	+0.773	+0.514	<.001	.005	3	3
GBM	LINC01422 →	+0.254	+0.361	.007	.004	3	3
UCEC	RPL17P13 →	-0.459	-0.556	.009	.001	3	3
UCEC	YBX1P8 →	-0.594	-0.816	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902564 vs SLC30A4 — CCRCC

Explore this scatter interactively →