Negative regulation of neutrophil activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of neutrophil activation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IQCN, MAP3K7CL, and HLCS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IQCN grouped by Negative regulation of neutrophil activation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IQCN →	+0.496	+0.877	.007	.009	3	4
SOFT_TISSUE	MAP3K7CL →	-3.201	-0.910	.003	.006	3	4
CNS	HLCS →	+0.732	+0.993	<.001	.001	3	4
BLOOD_Leukemia	NTSR1 →	-1.108	-0.680	.006	.002	3	4
SOFT_TISSUE	ATP7B →	+1.045	+1.377	.003	.001	3	3
SOFT_TISSUE	PFKFB2 →	+1.958	+1.269	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IQCN by Negative regulation of neutrophil activation activity — SOFT_TISSUE

Explore this box plot interactively →