Negative regulation of neutrophil activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of neutrophil activation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFAIP8L1, RASSF1, and TTPAL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neutrophil activation activity versus TNFAIP8L1 in SOFT_TISSUE (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TNFAIP8L1 →	+1.085	+1.604	.004	<.001	3	4
BLOOD_Leukemia	RASSF1 →	+1.001	+0.281	<.001	<.001	2	4
URINARY_TRACT	TTPAL →	+0.815	+1.798	.004	<.001	3	3
SKIN	SMTN →	+1.667	+1.703	.005	<.001	3	3
URINARY_TRACT	H2AC14 →	+1.123	+1.798	<.001	<.001	3	3
LUNG_NSCLC_LUAD	TBCK →	-0.547	-0.679	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902564 vs TNFAIP8L1 — SOFT_TISSUE

Explore this scatter interactively →