Regulation of neutrophil activation

Across TCGA cell cohorts, RNA activity of the Regulation of neutrophil activation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTN2A1, POP4, and FAM168A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neutrophil activation activity versus BTN2A1 in BONE (Pearson r = -0.95).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	BTN2A1 →	-1.265	-1.695	<.001	.001	3	5
BREAST	POP4 →	-0.744	-0.778	.003	.001	3	5
BLOOD_Myeloma	FAM168A →	-1.072	-1.555	.001	.002	3	4
BLOOD_Myeloma	ATP5F1D →	+0.952	+1.946	.001	<.001	3	4
BONE	LIN7A →	+4.390	+1.792	.001	.003	3	3
SOFT_TISSUE	PCDH12 →	+0.489	+1.826	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902563 vs BTN2A1 — BONE

Explore this scatter interactively →