Positive regulation of protein monoubiquitination

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein monoubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF12, PWWP2A, and ARL2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein monoubiquitination activity versus TAF12 in CCRCC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TAF12 →	+0.236	+0.105	<.001	.001	3	2
CCRCC	PWWP2A →	+0.234	+0.078	.002	.003	3	2
CCRCC	ARL2 →	+0.280	+0.136	.002	<.001	3	2
CCRCC	HMGB1P23 →	-0.273	-0.072	.007	.007	3	2
GBM	LAMTOR1 →	+0.161	+0.328	.001	.003	3	2
OV	RNF6 →	+0.331	+0.095	.004	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902527 vs TAF12 — CCRCC

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