Regulation of protein monoubiquitination

Across TCGA patient cohorts, RNA activity of the Regulation of protein monoubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEC24A, COG6, and GNL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein monoubiquitination activity versus SEC24A in GBM (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEC24A →	-0.202	-0.044	.002	<.001	3	5
UCEC	COG6 →	-0.190	-0.050	.002	.008	3	5
GBM	GNL1 →	+0.227	+0.045	<.001	<.001	3	5
UCEC	ANXA2_S164 →	-0.470	-0.061	.001	<.001	3	5
GBM	SGCD →	+0.500	+0.030	<.001	<.001	3	5
HNSC	HSF1 →	+0.141	+0.053	.006	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902525 vs SEC24A — GBM

Explore this scatter interactively →