Regulation of protein monoubiquitination

Across TCGA cell cohorts, RNA activity of the Regulation of protein monoubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OGFOD1, ZNF8, and CCDC171, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OGFOD1 grouped by Regulation of protein monoubiquitination-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OGFOD1 →	+0.535	+0.155	<.001	.002	3	4
BLOOD_Lymphoma	ZNF8 →	+0.946	+0.219	.002	.003	3	4
LUNG_SCLC	CCDC171 →	+1.023	+0.208	.006	<.001	3	4
BONE	DNAJC4 →	-1.370	-0.188	.001	<.001	3	3
BONE	PPP1R3B →	-1.060	-0.185	.001	<.001	3	3
PANCREAS	LPCAT4 →	+1.027	+0.165	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OGFOD1 by Regulation of protein monoubiquitination activity — SKIN

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