Regulation of protein monoubiquitination

Across TCGA cell cohorts, RNA activity of the Regulation of protein monoubiquitination pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR141, ATP6V1A, and ESR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPR141 grouped by Regulation of protein monoubiquitination-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GPR141 →	+0.235	+0.127	<.001	<.001	3	5
LIVER	ATP6V1A →	+0.379	+0.181	.008	<.001	3	4
CNS	ESR2 →	+0.145	+0.118	<.001	<.001	3	4
SKIN	DGKQ →	-0.233	-0.130	<.001	<.001	3	4
SKIN	STRN4 →	-0.399	-0.128	<.001	<.001	3	4
BREAST	HNRNPC →	+0.434	+0.132	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPR141 by Regulation of protein monoubiquitination activity — CNS

Explore this box plot interactively →