Positive regulation of protein K63-linked ubiquitination

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein K63-linked ubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAT1_S532, SAMHD1_S33, and SAMSN1_S23, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein K63-linked ubiquitination activity versus STAT1_S532 in CCRCC (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	STAT1_S532 →	+0.940	+0.072	<.001	<.001	3	6
CCRCC	SAMHD1_S33 →	+0.537	+0.054	<.001	<.001	3	5
CCRCC	SAMSN1_S23 →	+0.604	+0.063	<.001	<.001	3	5
HNSC	CTSL →	+0.261	+0.066	<.001	<.001	3	5
CCRCC	DEF6 →	+0.503	+0.061	<.001	<.001	3	5
LSCC	AIF1 →	+0.470	+0.067	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902523 vs STAT1_S532 — CCRCC

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