Positive regulation of protein K63-linked ubiquitination

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein K63-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLIC6, SLC6A14, and IFT122, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein K63-linked ubiquitination activity versus CLIC6 in HNSC (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CLIC6 →	-0.621	-0.269	.003	.004	3	3
HNSC	SLC6A14 →	+1.655	+0.389	<.001	.001	3	3
HNSC	IFT122 →	-0.435	-0.409	.007	.002	3	3
CCRCC	OR13J1 →	-0.113	-0.502	.009	.007	3	3
LUAD	LINC00885 →	-0.511	-0.591	<.001	<.001	3	3
LUAD	TOLLIP-AS1 →	-0.362	-0.556	.009	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902523 vs CLIC6 — HNSC

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