Positive regulation of protein K63-linked ubiquitination

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein K63-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF126, PNPT1, and PPP1CC, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein K63-linked ubiquitination activity versus RNF126 in STOMACH (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RNF126 →	+1.058	+0.366	.003	.003	3	8
LIVER	PNPT1 →	+1.446	+0.441	.001	<.001	3	6
LIVER	PPP1CC →	+1.025	+0.439	.001	<.001	3	6
LIVER	LAMA3 →	-3.300	-0.419	.007	.007	2	7
PANCREAS	KPNB1 →	+0.627	+0.495	.003	.001	3	6
SKIN	SEH1L →	+0.447	+0.304	.002	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902523 vs RNF126 — STOMACH

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