Regulation of organelle transport along microtubule

Across TCGA patient cohorts, RNA activity of the Regulation of organelle transport along microtubule pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP2, BORCS5, and RNA5SP118, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of organelle transport along microtubule activity versus MAP2 in UVM (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	MAP2 →	+1.934	+0.064	<.001	<.001	3	24
TGCT	BORCS5 →	+0.577	+0.052	<.001	<.001	3	21
ESCA	RNA5SP118 →	+1.052	+0.057	<.001	<.001	2	20
DLBC	FEZ1 →	+2.506	+0.053	<.001	<.001	2	19
MESO	TRIM46 →	+1.790	+0.060	<.001	<.001	3	18
ESCA	B4GALNT1 →	+1.303	+0.061	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902513 vs MAP2 — UVM

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