Regulation of organelle transport along microtubule

Across TCGA patient cohorts, RNA activity of the Regulation of organelle transport along microtubule pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNA5SP118, MAP2, and FGF14-AS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of organelle transport along microtubule activity versus RNA5SP118 in LSCC (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RNA5SP118 →	+1.719	+0.992	<.001	<.001	3	7
LSCC	MAP2 →	+2.018	+1.008	<.001	<.001	3	7
GBM	FGF14-AS1 →	+1.163	+0.393	<.001	<.001	3	5
CCRCC	TSPAN7 →	+1.065	+0.611	<.001	<.001	2	6
UCEC	ADGRV1 →	+1.112	+0.575	.005	.004	3	5
CCRCC	ZNF267 →	-0.299	-0.446	.007	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902513 vs RNA5SP118 — LSCC

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