Regulation of organelle transport along microtubule

Across TCGA cell cohorts, RNA activity of the Regulation of organelle transport along microtubule pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RSC1A1, TSFM, and NDUFA4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RSC1A1 grouped by Regulation of organelle transport along microtubule-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RSC1A1 →	-1.434	-0.331	.001	.005	3	4
UPPER_AERODIGESTIVE_TRACT	TSFM →	-0.938	-0.313	.006	.007	3	4
UPPER_AERODIGESTIVE_TRACT	NDUFA4 →	-1.354	-0.317	.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	EIF2B3 →	-0.970	-0.347	.006	.001	3	4
URINARY_TRACT	NDUFA9 →	-0.540	-2.043	.006	<.001	3	4
STOMACH	KLC3 →	+3.510	+1.596	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RSC1A1 by Regulation of organelle transport along microtubule activity — OESOPHAGUS

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