Regulation of organelle transport along microtubule

Across TCGA cell cohorts, RNA activity of the Regulation of organelle transport along microtubule pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNAB3, CDC16, and NAXD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of organelle transport along microtubule activity versus KCNAB3 in BLOOD_Leukemia (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KCNAB3 →	-1.604	-0.323	.001	.004	2	6
STOMACH	CDC16 →	+1.488	+0.421	.001	.002	3	4
STOMACH	NAXD →	+1.437	+0.347	.002	.005	3	4
LUNG_SCLC	LRRC36 →	+0.955	+0.252	.001	.001	3	4
LARGE_INTESTINE	ZNF232 →	-1.147	-0.279	.005	.005	3	4
LUNG_SCLC	ABLIM2 →	+2.350	+0.280	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902513 vs KCNAB3 — BLOOD_Leukemia

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