Regulation of apoptotic DNA fragmentation

Across TCGA patient cohorts, RNA activity of the Regulation of apoptotic DNA fragmentation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MNDA_S227, ZMYM4_S1241, and FGR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of apoptotic DNA fragmentation activity versus MNDA_S227 in COAD (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MNDA_S227 →	+0.827	+0.041	.006	.009	3	5
GBM	ZMYM4_S1241 →	+0.351	+0.046	.001	<.001	3	5
LSCC	FGR →	+0.426	+0.035	<.001	.001	3	4
HNSC	ZNF318_S464 →	+0.317	+0.039	<.001	.004	3	4
HNSC	SLC3A2 →	-0.550	-0.057	.002	.005	3	3
HNSC	MSH6 →	+0.331	+0.043	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902510 vs MNDA_S227 — COAD

Explore this scatter interactively →