Regulation of apoptotic DNA fragmentation

Across TCGA patient cohorts, RNA activity of the Regulation of apoptotic DNA fragmentation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRK, PPIL6, and CELA2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of apoptotic DNA fragmentation activity versus FRK in BRCA (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FRK →	+0.911	+0.200	<.001	<.001	3	4
LSCC	PPIL6 →	+0.521	+0.234	.001	.001	3	4
PDAC	CELA2B →	+1.608	+0.105	.008	.001	2	5
LSCC	E2F3P2 →	+0.262	+0.161	.004	.007	3	4
CCRCC	JPT2 →	+0.408	+0.107	<.001	.002	3	3
LUAD	FOXJ1 →	+1.104	+0.138	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902510 vs FRK — BRCA

Explore this scatter interactively →