Regulation of apoptotic DNA fragmentation

Across TCGA cell cohorts, RNA activity of the Regulation of apoptotic DNA fragmentation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRXL2B, WRAP73, and C3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of apoptotic DNA fragmentation activity versus PRXL2B in BLOOD_Leukemia (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRXL2B →	+1.260	+0.188	.001	<.001	3	5
LUNG_NSCLC_LUAD	WRAP73 →	+0.629	+0.757	.002	.008	3	4
PANCREAS	C3 →	-3.379	-1.202	<.001	<.001	3	4
PANCREAS	ISCA1 →	+0.739	+1.017	.001	.005	3	4
PANCREAS	ARRB2 →	+1.229	+1.044	<.001	.004	3	4
PANCREAS	MRM3 →	+0.803	+1.353	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902510 vs PRXL2B — BLOOD_Leukemia

Explore this scatter interactively →