L-alpha-amino acid transmembrane transport

Across TCGA cell cohorts, RNA activity of the L-alpha-amino acid transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAP, CST3, and CARS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAP grouped by L-alpha-amino acid transmembrane transport-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FAP →	-1.439	-1.053	.006	.001	3	4
BREAST	CST3 →	-1.808	-0.715	.004	.002	3	4
LIVER	CARS2 →	-0.696	-1.384	.007	<.001	3	4
LIVER	NPIPB13 →	-0.593	-1.238	.002	<.001	3	4
PANCREAS	C16orf95 →	+0.827	+1.048	.003	.004	3	4
LARGE_INTESTINE	PLGLB2 →	+0.577	+0.981	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAP by L-alpha-amino acid transmembrane transport activity — STOMACH

Explore this box plot interactively →